Two of the Premier League’s four unbeaten teams meet in North London on Saturday (12.30pm ET; 5.30pm BST) as they look to continue their promising starts to the new campaign. Spurs came away with an impressive 2-2 draw away to Arsenal last time out, while Liverpool overcame West Ham by three goals to one.
The Reds are second in the table with 16 points while Tottenham Hotspur are just two points and two places behind. With Spurs enjoying home advantage, the sides appear to be evenly matched, but what are the USA bookmakers expecting? Read on for our full EPL matchup preview with picks and betting predictions.
There are odds against figures on all three possible moneyline outcomes in this game, but Liverpool will start as favorites for the three points. Jurgen Klopp’s side are available at best industry odds of 6/5 while victory for Spurs can be found at 2/1 in places. The draw completes the match betting options, and this is quoted at 3/1.
Liverpool have won five and drawn one of their first six league games this season. Tottenham are also unbeaten with four wins and two draws. Arguably, Spurs have played the better teams with both Arsenal and Manchester United appearing in their opening six fixtures.
Reds’ fans would argue that they won away at Newcastle, but Tottenham’s challenges have been marginally tougher overall. Liverpool played in midweek in the EFL Cup while Spurs rested, but the home side have injury concerns over Brennan Johnson and their playmaker James Maddison.
Overall, it’s evenly balanced, so let’s consider some side bets before making our betting predictions and giving our picks and tips verdict for this preview.
Two goals for Son Heung-Min in last Sunday’s North London Derby mean that he is clear as Spurs’ leading scorer with five in the league. Son is one of two joint favorites in the first goalscorer market and you can back the Tottenham captain at 11/2. Liverpool’s Mo Salah is also on offer at best odds of 11/2, while his teammate Darwin Nunez is marginally further back at a top price of 6/1.
Spurs’ Richarlison is more likely to start on the bench, so backers should be wary of his odds of 7/1, but Liverpool’s Diogo Jota is worth considering at 15/2. Jota was on target in the 3-1 win over Leicester City in midweek and he also has two league goals this season. Behind the main front men, some longer-odds options might include Spurs’ James Maddison at 8/1 and Liverpool’s Dominik Szoboszlai at 14/1.
In other side bets, Both Teams to Score can be claimed for Saturday’s fixture at best odds of just 4/11. Those that prefer the ‘No’ option on BTTS can claim a top price of 11/5.
In the Total Combined Goals betting, a stake Over the 2.5 line will current attract a best of 2/5 but, if we push that to Over 3.5 goals, this will just touch the evens (1/1) mark. Anyone expecting a quiet 90 minutes at the Tottenham Hotspur Stadium could stake Below the 2.5 goal line to find a top price of 2/1.
As for Correct Score suggestions, the sportsbooks’ verdict is that Liverpool will secure a narrow victory, so there could be some interest in a 2-1 away win at best odds of 10/1. The same scoreline in favor of Tottenham Hotspur can be found at a best of 11/1, while the 2-2 draw is also listed at that same top price of 11/1.
Our Preview’s THFC vs LFC Betting Picks & Predictions Verdict
Many are waiting for Ange Postecoglou’s honeymoon period at Spurs to collapse, but it hasn’t happened yet. Last weekend at Arsenal, THFC showed that they can compete against the top sides and Saturday will provide another big test.
Spurs can maintain their good form, but Liverpool are something of a bogey team. The Reds have not lost to Tottenham since 2017 and they have won nine and drawn three of the last 12 games between these two clubs.
Liverpool’s recent run is seriously impressive. Since drawing away to Chelsea on the opening day of the season, Jurgen Klopp’s men have won seven straight games in all competitions. Interestingly, they have won each of their last four matches via a 3-1 scoreline. An identical outcome on Saturday is possible, but Spurs should make it a tighter game. The bookmakers suggest a high scoring away win, and we feel that they have got it right this time.
Liverpool for the win is our first pick and, while the Over 3.5 Goals bet is relatively short at evens (1/1) this week, it looks a likely bet.
For the neutrals, this promises to be the most entertaining fixture of the weekend, and hopefully this preview can pick up some profits to enhance that entertainment with these betting predictions and picks. In summary:
- Liverpool to win on the moneyline at +120 with Bovada or BetOnline.
- Over 3.5 total goals at evens (1/1 or +100) with BetOnline or EveryGame.

Matt Harris is a golf and soccer expert for USA Betting. His other area of specialist knowledge is cricket. He is well known in sports journalism and contributes articles to a plethora of big-name websites and media outlets. Titles that he writes or has written for include: Betfair, BetVictor, Unibet & Just Bookies.